Nutritional studies on DAO deficiency
DAO deficiency is a disorder in the metabolism of dietary histamine that occurs when there is low activity of the enzyme Diamine Oxidase (DAO), that is, when for some reason there is a significant deficiency in the functional activity of the enzyme that is most important for histamine metabolism.
When there is a disproportion between ingested histamine or histamine released by the cells that store it in the body and the ability to metabolize it, histamine accumulates in the plasma, causing adverse effects.
For this reason, it is essential to create a nutritional plan tailored to each individual, low in histamine and, if necessary, supplemented with the DAO enzyme.
There are several conditions associated with increased histamine due to low DAO enzyme activity:
- Migraine or other vascular headaches.
- Gastrointestinal disorders: constipation, diarrhea, satiety, bloating, or cyclic vomiting syndrome.
- Chronic fatigue and fibromyalgia.
- Dermatological disorders such as dry skin, atopic skin, or psoriasis.
- Osteoarticular and muscular pain.
- In childhood and adolescence, DAO deficiency has been linked to attention-deficit/hyperactivity disorder (ADHD).
